Polynucleotides (PDRN) Leicester
Advanced Skin Regeneration & Deep Tissue Repair with Polynucleotides , naturally restore collagen, elastin, and radiant skin from within.
5.0120+ reviews
4.7140+ reviews
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About This Treatment
What are Polynucleotides?
Polynucleotides (PDRN) are pharmaceutical-grade DNA fragments derived from purified salmon or trout that act as powerful biological signals within the skin. When injected, they bind to A2 adenosine receptors and activate fibroblasts , the cells responsible for producing collagen and elastin , triggering deep tissue regeneration and repair.
Unlike treatments that simply add volume or hydrate the surface, polynucleotides address the root cause of skin ageing: declining cellular repair capacity. Results develop gradually as your own biology responds, producing naturally rejuvenated skin with superior hydration, firmness, and radiance.
Quick Facts
Polynucleotides Treatment at a Glance
Our Approach
Our Polynucleotides Approach
At The One Clinic, our polynucleotides protocol is built on three core pillars , precise assessment, targeted delivery, and progressive regeneration , ensuring every patient achieves genuine, lasting skin improvement.
Skin Assessment
A thorough skin consultation evaluates your skin quality, concerns, and regenerative needs. We assess hydration levels, elasticity, fine lines, and tissue damage to create a fully personalised polynucleotides protocol.
Targeted Injection Protocol
Pharmaceutical-grade PDRN is precisely micro-injected into the dermis across mapped treatment zones. Our advanced technique ensures optimal distribution for maximum collagen stimulation and cellular repair.
Progressive Regeneration Plan
A course of 3 to 4 sessions builds collagen progressively. We monitor your skin's response and adjust the protocol at each visit, then schedule maintenance treatments to sustain your results long term.
The Outcome
When assessment, injection protocol, and regeneration planning work together, polynucleotides deliver complete skin renewal , addressing cellular decline, dehydration, and collagen loss in a single, progressive treatment programme.
What to Expect
Your Treatment Journey
Consultation & Skin Assessment
A detailed review of your skin quality, concerns, and goals. Your doctor assesses hydration, elasticity, and areas of concern to confirm that polynucleotides are the right choice and to build your personalised treatment plan.
Treatment Preparation
The skin is thoroughly cleansed and a topical numbing cream applied for complete comfort. Treatment zones are mapped and the pharmaceutical-grade PDRN solution prepared for precise delivery.
Injection Sessions
Using advanced micro-injection technique, polynucleotides are delivered into the dermis across all target areas. The 30,45-minute procedure is comfortable and requires no general anaesthesia.
Progressive Regeneration
Cellular regeneration begins within days. Visible improvement appears at 2,4 weeks, deepening over 8,12 weeks as collagen and elastin production builds. Maintenance sessions every 3,6 months preserve results.
Polynucleotides Treatment Benefits
Deep Tissue Regeneration
PDRN molecules signal fibroblasts to activate and repair tissue at a cellular level, driving true regeneration rather than simply masking signs of ageing.
Stimulates Collagen & Elastin
Growth factors including VEGF and TGF-β are activated, boosting collagen and elastin production for firmer, smoother, and more resilient skin over time.
Superior Hydration
Polynucleotides attract and retain moisture deep within the dermis, improving skin plumpness, hydration levels, and the quality of the skin barrier from within.
Reduces Fine Lines
Progressive collagen remodelling softens fine lines and surface wrinkles, restoring a smoother, more youthful skin texture without altering natural expression.
Anti-inflammatory Effect
PDRN binds to A2 adenosine receptors, modulating inflammation and supporting healing , making polynucleotides ideal for sensitive, reactive, or post-procedure skin.
Long-lasting Results
Because polynucleotides stimulate your own tissue repair, results are natural and durable. With periodic maintenance sessions, the improvements can be sustained indefinitely.
Is This Right for You?
Who is Suitable for Polynucleotides?
Polynucleotides are suitable for adults who experience:
- Ageing skin with loss of firmness, radiance, or elasticity
- Under-eye hollows or dark circles due to poor skin quality
- Skin laxity on the face, neck, décolletage, or hands
- Chronic skin dehydration and dullness
- Post-procedure healing and skin repair support
Treatment is not suitable for those with:
- Known allergy to fish or seafood
- Active skin infections or inflammation in the treatment area
- Pregnancy or breastfeeding
- Autoimmune conditions affecting the skin
A consultation with our doctors will confirm your suitability and tailor the ideal protocol for your skin.
How Do Polynucleotides Work?
Polynucleotides contain long-chain DNA fragments (PDRN) sourced from purified salmon or trout. When micro-injected into the dermis, these molecules bind to A2 adenosine receptors on the surface of fibroblast cells. This receptor activation triggers an intracellular signalling cascade that switches on the cells' repair and regeneration programmes.
Activated fibroblasts begin producing collagen, elastin, and hyaluronic acid at an accelerated rate. Concurrently, key growth factors including VEGF (vascular endothelial growth factor) and TGF-β (transforming growth factor beta) are upregulated, further promoting tissue repair and angiogenesis. The result is genuine, progressive skin regeneration that unfolds over weeks as the body remodels its own architecture.
Polynucleotides Address
- Collagen & elastin depletion
- Skin dehydration & barrier loss
- Fine lines & surface wrinkles
- Under-eye hollows & dark circles
- Post-procedure skin repair
- Hair follicle regeneration
Post-Treatment
Results, Aftercare & Side Effects
When Will You See Results?
Mild redness and minimal swelling may occur for 24 to 48 hours immediately after treatment. Initial improvements in hydration and skin texture appear within 2 to 4 weeks as cellular regeneration activates.
Progressive improvement continues over 8 to 12 weeks, with skin texture and hydration notably improved by session three. Annual booster sessions maintain and extend results indefinitely.
Side Effects
Polynucleotides are highly biocompatible. Most patients experience only minor, temporary effects:
- Mild redness or warmth at injection sites
- Minor swelling or tenderness for 24,48 hours
- Small needle marks that resolve quickly
Allergic reactions are extremely rare due to the biocompatibility of PDRN. Serious complications are very uncommon when performed by a trained clinician.
Aftercare Tips
- Avoid heat, saunas, and intense exercise for 24,48 hours
- Keep skin clean and well-hydrated
- Apply broad-spectrum SPF 30+ daily during healing
- Avoid touching or rubbing treated areas
- Follow your doctor's specific aftercare advice
Real Results
Skin Concerns Polynucleotides Address
Polynucleotides can significantly improve a wide range of skin concerns treated at The One Clinic, Leicester.
Under-eye Hollows
PDRN regenerates the delicate periorbital tissue, improving hollow appearance and dark circles caused by thinning skin.
Fine Lines & Wrinkles
Progressive collagen stimulation smooths surface lines and restores youthful skin texture across the face and neck.
Skin Dehydration
Polynucleotides dramatically improve deep hydration, leaving skin plump, radiant, and resilient against environmental stress.
Loss of Elasticity
Elastin production is revived to restore the skin's natural bounce and firmness, reversing early signs of sagging.
Dull Complexion
Cellular renewal and improved microcirculation restore luminosity, giving skin a healthy, rested, and energised glow.
Acne Scars
Tissue repair and remodelling at the injection site reduce the appearance of acne scarring and post-inflammatory marks.
Neck & Décolletage Ageing
Crepey, thin skin on the neck and chest responds well to polynucleotides, with notable firming and texture improvement.
What Our
Customers Say
Don't just take our word for it. Here's what real patients have to say about their experience at The One Clinic.
Regenerate. Restore. Radiate.
Let our experts create your personalised polynucleotides regeneration plan!
Treatment Areas
Where Can Polynucleotides Be Used?
Polynucleotides can regenerate skin quality across a wide range of face, body, and scalp areas, addressing both cosmetic and functional concerns.
Face & Body Areas
- Full face
- Under-eye / periorbital
- Neck
- Décolletage
- Hands
- Scalp / hair loss
Skin Concerns
- Fine lines & wrinkles
- Hollowness
- Skin dehydration
- Pigmentation
- Scarring
- Hair thinning
- Loss of firmness
Polynucleotides Treatment
Best Polynucleotides
Leicester Experience
Experience the best polynucleotide (PDRN) treatment in Leicester at our clinic. Our expert doctors deliver safe, precisely targeted regenerative injections for the face, neck, under-eyes, and body. Enjoy natural, progressive results with minimal downtime and personalised care tailored to your skin's unique biology.
Polynucleotides Cost at The One Clinic
Polynucleotides from £300 per session
The final price depends on your personalised treatment plan and the areas being treated. Full pricing will be discussed during your consultation with our expert.
Why Choose The One Clinic For Polynucleotides
All-in-one clinic with medical & aesthetic services.
Highly trained, compassionate doctors.
Customised treatments based on listening & expertise.
State-of-the-art facilities & modern equipment.
Strong reputation & excellent reviews.
Comprehensive care and referrals with specialists.
Meet the Experts
Dr Sumit Virmani
MBBS, MRCGP
Co-Founder & GP
Dr Sumit Virmani is co-founder of The One Clinic. He has extensive experience having worked as a medical doctor for over 15 years, with over 12 of these years working as a local GP.
View Full ProfileFAQ
Frequently Asked Questions
Polynucleotides (PDRN , polydeoxyribonucleotide) are long-chain DNA fragments derived from salmon or trout, purified to pharmaceutical grade. When injected into the skin, they bind to A2 adenosine receptors and activate fibroblasts, triggering the production of collagen, elastin, and key growth factors such as VEGF and TGF-β. This stimulates genuine tissue regeneration at a cellular level.
Most adults concerned about skin quality decline, dehydration, fine lines, or loss of elasticity are suitable candidates. Treatment is not recommended for those with a fish or seafood allergy, active skin infections, pregnancy or breastfeeding, or certain autoimmune conditions. A consultation with our doctors will confirm your suitability.
A course of 3 to 4 sessions spaced 2 to 4 weeks apart is typically recommended for optimal results. This sequential approach builds collagen progressively. Following the initial course, maintenance sessions every 3 to 6 months sustain results long term. Your doctor will tailor the protocol to your individual skin goals.
Initial improvements in hydration and skin quality are usually visible within 2 to 4 weeks as cellular regeneration activates. Results deepen progressively over 8 to 12 weeks as collagen and elastin production builds. Optimal outcomes are typically evident after the full course of treatment.
The procedure is very comfortable. A topical numbing cream is applied beforehand, and most patients report only minimal sensation during the 30 to 45-minute session. Post-treatment discomfort is mild , some redness or swelling may occur but usually resolves within 24 to 48 hours.
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